Immune Sensing of Candida albicans

Candida albicans infections range from superficial to systemic and are one of the leading causes fungus-associated nosocomial infections. The innate immune responses during these various infection types differ, suggesting that host environment plays a key role in modulating host–pathogen interaction. In addition, C. is able remodel its cell wall response environmental conditions evade clearance mechanisms establish niches, such as oral vaginal mucosa. Phagocytes play clearing albicans, which primarily mediated by Pathogen Associated Molecular Pattern (PAMP)–Pattern Recognition Receptor (PRR) interactions. PRRs Dectin-1, DC-SIGN, TLR2 TLR4 interact with PAMPs β-glucans, N-mannan O-mannan, respectively, trigger activation cells. Innate cells exhibit distinct yet overlapping repertoires PAMPs, resulting preferential recognition particular morphotypes them. phagocytes context individual also differs, neutrophils playing prominent kidney infections, dendritic skin this review, we provide an overview receptors involved detection discuss differential seen different vulvovaginal candidiasis (VVC) candidiasis.